3 essential ceramides that improves the appearance of fine lines and wrinkles in 4 weeks and provides 24-hour hydration . CeraVe's Renewing Retinol Facial Serum , developed in collaboration with dermatologists , helps restore the protective epidermal barrier and ceramides that decrease with age, while it has been clinically proven to give smoother, softer skin with virtually zero irritation. Clinically proven to deliver a 38% improvement in rough texture for smoother skin in just 2 weeks, with zero irritation. This lightweight, non-greasy serum absorbs instantly into the skin, leaving it feeling softer and smoother, as well as visibly improving health, radiance, firmness and the appearance of pores. It has been tested under dermatological control and is suitable for all skin types , including sensitive skin . The skin does not show dryness or peeling. It is recommended to use the product once every night.